Other results sustain that despite the significant increases in Th17 and IL-17 CD4+ T cells in the blood of RA patients, these did not correlate with ESR, CRP, or DAS28, suspecting that the presence of IL-17 producing CD4+ T cells in the blood from patients with established RA is of limited use as a biomarker to indicate disease activity [44]. The gene discussed is CRP; the disease is rheumatoid arthritis.