One example is S100P that encodes a member of small calcium-binding proteins family and is highly expressed in NSCLC. S100P played a key role downstream for Keap1-Nrf2 interaction. Keap1 encodes E3 ligase and is involved in cellular defense response to oxidative stress through an interaction with nuclear factor erythroid-2-related factor 2 (Nrf2). The gene discussed is KEAP1; the disease is non-small cell lung carcinoma.