CASP3 and epilepsy: GABAAR subunit mutations or genetic variations can lead to its dysfunctions, which have been thought to participate in the pathomechanisms of epilepsy [24], in which multiple GABAAR epilepsy mutations result in protein misfolding and may cause degradation or retention of the protein molecules in cells; Kang et al. found that mutant GABAAR  γ2 subunits accumulate and aggregate intracellularly, activated caspase-3, and caused widespread and age-dependent neurodegeneration; these findings suggested the epilepsy-associated mutant γ2 subunit played important role in neurodegeneration [25].