The pathological plasticity of neuronal spines and synapses is important in the pathological process of epilepsy; thus, we studied the activation levels of Rac1 and Cdc42 to explore whether Rac1 and Cdc42 are regulated by the miR-132/p250GAP pathway in our SRED model of cultured hippocampal neurons. This evidence concerns the gene RAC1 and epilepsy.