Here, we investigated the activation levels of the dendritic growth promoting factors Rac1/Cdc42 and further demonstrated, that under the condition of aberrant neuronal activity of epileptic discharge, miR-132 and p250GAP principally regulated the activation level of Cdc42, which indicated that Cdc42 might be a more appropriate target for further study about miR-132 and epilepsy. Here, RAC1 is linked to epilepsy.