The primary pathways were immune (B-cell receptor, T-cell receptor, and primary immunodeficiency), inflammation (MAPK, VEGF, and PI3K/Akt), cell movement (Gap junction), airway remodeling of the cytoskeleton and extracellular matrix (regulation of actin cytoskeleton and actin cytoskeleton), cell adhesion (CAMs), and signal transduction (adherens junction and focal adhesion). This evidence concerns the gene AKT1 and inborn error of immunity.