INS and polycystic ovary syndrome: Other authors confirmed that administration of MI (2 g daily) plus folic acid in overweight women with PCOS improved insulin-sensitivity, biochemical hyperandrogenism and regularity of menstrual cycles [66] similar to the effect obtained using insulin sensitizers such as metformin [67], congruently with previous studies which showed recovery of menstrual cycles and a reduction in insulin plasma level also after oral glucose tolerance test [68].