We already showed that the administration of either MI (4 g/die) or DCI (1 g/die) together with folic acid to two different groups of PCOS patients showed in both groups an improved systolic blood pressure, a reduction in circulating androgens levels, a reduction in LH and LH/FSH ratio, an increased insulin sensitivity evaluated through decreased HOMA index, and increased SHBG. The gene discussed is BRD2; the disease is polycystic ovary syndrome.