One of the first studies carried out in overweight and obese patients with PCOS showed that the administration of DCI 1200 mg once daily for six to eight weeks led to a reduction of testosterone level, improved metabolic parameters, decreased insulin response to orally administered glucose, ameliorated systolic and diastolic blood pressure, triglycerides level, and ovulatory function [38]. Here, INS is linked to polycystic ovary syndrome.