CD4+ lymphocytes from patients with HD and controls did not differ regarding the production of cytokines [IL-2, IL4, IL-6, IL-8, IL-5, IL-13, interferon- (IFN-) γ, IL-10, IL-1b, IL-12p70, and TNF-α] upon anti-CD3/CD-28 antibodies stimulation [38]. Here, CD28 is linked to Huntington disease.