MMP-9 was detected by ISH (in situ hybridization) in the stromal fibroblasts adjacent to tumor invasion sites in infiltrating basal cell and squamous cell carcinomas and in the eosinophils infiltrating the dermis in response to invasive BCC [50, 51] and another study found an increased expression of MMP-9 and MMP-2 in SCC versus BCC [52]. The gene discussed is MMP2; the disease is skin basal cell carcinoma.