In a mixture of A549, H596, H322M and H441 lung tumor cells with different expression levels of HER1, HER3, IGF1R and cMet similar to the heterogenous cell populations in tumors, TsAb2v2 and TsAb3v1 induced a significantly improved tumor growth inhibition in comparison with the corresponding BsAbs. This evidence concerns the gene EGFR and neoplasm.