To provide further insight into the role of TNFα −308 A/G, −238 A/G, and −857 C/T polymorphisms in predicting treatment outcome of TNFα blockade in patients with SpA (PsA/Ps, AS, IBD/CD), we performed an intensive meta-analysis of published data and one set of unpublished data from our lab. The gene discussed is TNF; the disease is inflammatory bowel disease.