Considering the close relationship between ADIPOQ +45 T > G and the typical components of MS as well as the many resulting potential disease risks such as obesity, cancer, and hypertension, we summarized data from the published meta-analyses as well as the primary meta-analysis in our study (Fig. 2, Supplementary Table S2). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.