ADIPOQ and obesity due to melanocortin 4 receptor deficiency: ADIPOQ +45T>G (rs2241766) is one of the most common variants of exon 2 on the ADIPOQ gene, and some studies have provided evidence that the ADIPOQ +45 T>G polymorphism is associated with serum levels of adiponectin3, MS components, insulin sensitivity, obesity and T2DM8.