CDH13 and urinary bladder carcinoma: The pooled OR from 5 studies including 174 advanced bladder cancer patients and 345 early stage bladder cancer patients indicated that CDH13 methylation was significantly higher in advanced stage tumors than in early stage tumors (OR = 3.42, 95 % CI = 1.72–6.80, P < 0.001) (Fig. 4).