GRM5 and epilepsy: In the immunofluorescence assays, the expression of mGluR5 was significantly upregulated in epileptic rats only administrated intraperitoneally with Licl-pilocarpin compared to others, whereas the rats before intragastric administration of pu-erh tea or diazepam showed reduced expression of mGluR5 compared to that in epilepsy (Fig. 7d, e).