KIAA1549 and central nervous system cancer: In addition to H3K27M, genetic aberrations affecting the RAS-MAPK pathway including KIAA1549-BRAF and other BRAF, RAF and FGFR fusion events, as well as BRAF and FGFR1 point mutations have been described primarily in hemispheric low grade gliomas in adults and children [7, 18, 19, 30, 34].