MAPK8 and silicosis: Our group previously reported that Ac-SDKP has a beneficial effect upon silicosis, which involved the attenuation of TGF-β1 and Ang II signaling, pulmonary fibroblast proliferation, and collagen synthesis via c-Jun N-terminal kinase (JNK) signaling, as well as the regulation of myofibroblast differentiation by serum response factor (SRF)8, 9.