CNR1 and schizophrenia: In hippocampal slice cultures (Khaspekov et al. 2004), and in cultured neurons (Kim et al. 2006), it has been demonstrated that endocannabinoid system through cannabinoid (CB: CB1 and CB2) receptors is involved in the control of NMDA receptors-related neuronal dysregulation, connected with schizophrenia-like symptoms.