Higher levels of peripheral inflammatory markers are associated with cerebral microbleeds in aging patients [12], high levels of circulating tumor necrosis factor receptor 2 are observed in subjects with cerebral microbleeds [13], and higher activity of lipoprotein phospholipase-A2 (a marker of vascular inflammation) is related to the presence of deep cerebral microbleeds in subjects who were carriers of at least one APOE ε2 or ε4 allele [14]. This evidence concerns the gene APOE and cerebral microbleeds.