Existing mouse models of CMH include mice that over-express mutant amyloid precursor protein to study cerebral amyloid angiopathy (CAA)-associated CMH [2], hypertensive mice [5] to study hypertension-associated CMH, and the hypoxia-reoxygenation-induced CMH mouse model to study high-altitude-associated CMH [33]. This evidence concerns the gene APP and hypertensive disorder.