We previously found that children with PMS younger than 3 years of age have a higher natural developmental rate than children older than 3 years of age, who increasingly deviate from the typical developmental rate.3 Interestingly, subgroup analyses in children older than 36 months suggested a stronger effect of intranasal insulin in this group and showed significant results for the effect of intranasal insulin for the domains of cognition and social skills (Table 3). The gene discussed is INS; the disease is premenstrual tension.