CXCL8 and delirium: For IL-8, we identified a significant increase in the POCD/delirium group compared to baseline at all time points (3 h p = 0.0161; 6 h p < 0.0001; 18 h p < 0.0001), and in the group without cognitive postoperative changes at 6 h (p = 0.0039) and 18 h (p = 0.0014).