Individual data sets and meta-data showed that the prognostic value of the CES remained significant after adjusting for other factors, including tumour stage and individual staging factors, tumour grade, breast cancer ER status, HER2 status, and NSCLC histological subtype (Figs 3g and 4h; Supplementary Tables 15–27). The gene discussed is ERBB2; the disease is breast carcinoma.