However, using competition binding with recombinant monoclonal antibodies, anti-GAD65 antibodies from stiff person syndrome were found to recognize a linear epitope on residues 4–22 and two conformational epitopes spanning residues 308–365 and 451–585 in ~30 and ~70 % patients, respectively [47] (Fig. 1e). The gene discussed is GAD2; the disease is stiff-person syndrome.