Notably, among the differentially expressed lncRNAs which have already been observed, associations between HOX antisense intergenic RNA (HOTAIR), metastasis-associated- in-lung-adenocarcinoma-transcript-1 (MALAT1), BRAF activated noncoding RNA (BANCR),SPRY4 intronic transcript 1 (SPRY4-IT1) and antisense noncoding RNA in the INK4 locus (ANRIL) with NSCLC have been reported, which directs that these lncRNAs may be the novel modulators in the process of metastasis in human NSCLC [14, 20–23]. Here, SPRY4 is linked to non-small cell lung carcinoma.