Meanwhile, relative high levels of PD-1 and TIM-3 in CD8+ T cells of esophageal cancer patients (n = 10) were noted, although the differences (vs. healthy donors) were not significant (cancer patients vs. healthy donors, 27.85 ± 7.199% vs. 15.86 ± 3.282%, p = 0.1470; 32.56 ± 6.237% vs. 19.70 ± 3.579%, p = 0.0905; Figure 2). The gene discussed is HAVCR2; the disease is esophageal cancer.