CD4 and neoplasm: We observed statistically significant correlations between PD-1 and TIM-3 expression in CD4+ T cells in PBMC (r = 0.5270, p = 0.0011; Figure 5A) and tumor tissues (r = 0.4254, p = 0.0340; Figure 5C), as well as in CD8+ T cells in PBMC (r = 0.7110, p < 0.0001; Figure 5A), AEM (r = 0.5641, p = 0.0033; Figure 5B) and tumor tissues (r = 0.5148, p = 0.0058; Figure 5C).