Metformin probably influences mitochondria in cancer cells to reduce tumorigenesis [27, 28], and inhibits both insulin-like growth factor (IGF) signaling and mTOR; it also modulates AMP kinase (AMPK), represses the AKT/mTOR pathway, eliminates cancer stem cells (CSCs) and inhibits tumor growth [29]. This evidence concerns the gene MTOR and neoplasm.