CD4 and colitis: One example is the study by Yamamoto et al. [49], in which treatment of murine colitis induced by adoptive transfer of CD4+ CD45RBhi T cells with antibodies to IL-6 receptor (IL-6R) reduced T cell expansion and attenuated the expression of molecules that promote interaction between leucocytes and endothelial cells, such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), which are required for cell infiltration.