VEGFA and neoplasm: Pigment epithelium-derived factor (PEDF) is an endogenous 50 kDa glycoprotein disseminating throughout the body5, which has been proved to present not only direct anti-tumor properties of apoptosis6, differentiation and anti-proliferation7 of tumor cells but also indirect characters like anti-angiogenesis8 possibly through vascular endothelial growth factor (VEGF) and inducing apoptosis of endothelial cells.