We compared early tumors of PCa (defined as Gleason score ≤6 or T2 pathological stage) with normal prostate tissue (P), but we also compared all PCa with P. We identified the same statistically significant differences in the two comparisons except for these genes: CDH13, RUNX3 in training set and HIC1 in validation set. Here, RUNX3 is linked to posterior cortical atrophy.