Administration of NTS to Tmsb4x−/y mice also significantly increased plasma creatinine (P < 0.01) (Figure 3d), impaired creatinine clearance (P < 0.01) (Figure 3e), and raised the blood urea nitrogen level (P < 0.05) (Figure 3f) compared with Tmsb4x+/y mice with NTS nephritis. This evidence concerns the gene TMSB4X and nephritis.