TMSB4X and glomerulosclerosis: NTS nephritis involves the injury of intrinsic glomerular cells, including podocytes, as well as leukocyte infiltration, glomerulosclerosis, and tubulointerstitial fibrosis,33 processes in which Tmsb4x has been implicated.10, 16 We predicted that the lack of global Tmsb4x may exacerbate NTS nephritis severity and examined this in 3-month-old Tmsb4x−/y and Tmsb4x+/y mice (Figure 3a).