JUP and keloid: Keloid scars in vivo exhibit adhesion defects, including abnormal localization of desmosome components plakophilin 1 and junction plakoglobin (also known as γ-catenin), a core EMT gene that encodes a component of adherens junctions [9], and keloid scars were found to exhibit ultrastructural alterations of the basement membrane zone (BMZ) [21].