However it has to be noted that recombinant EPO has been shown to be ineffective in preventing the anemia that occurs after a major burn injury and does not reduce the need for ongoing blood transfusions.[133] This resistance to EPO treatment may be due to dampened erythropoiesis and lymphopoiesis and enhanced myelopoiesis in the bone marrow as demonstrated following burn injury in animal models.[134]. This evidence concerns the gene EPO and anemia (phenotype).