Nevertheless, Il-2 or IL2RA are genetic loci with confirmed associations with T1D, rheumatoid arthritis (RA), celiac disease, multiple sclerosis (MS), and Graves’disease (GD).[37] The unsuccessful trial of IL-2 therapy in T1D should not halt further research in understating IL-2-Treg pathway. This evidence concerns the gene IL2 and type 1 diabetes mellitus.