Angiogenin drives endothelial cells toward a stimulus to initiate the complex process of angiogenesis.[21] Angiogenesis is often induced in inflammatory joint diseases, whereby the level of angiogenin in the synovial fluid of patients with acute synovitis (104 ng/ml) has been shown to be significantly higher than in those patients with osteoarthritis (20 ng/ml).[22] The abundant expression of angiogenin in burn blister fluids indicates an association between an increased release of angiogenin with the need for neovascularization in acute burn injuries.[19]. This evidence concerns the gene ANG and acute synovitis.