Aberrant AMPK expression or activity may therefore compromise system responses to hypoxia or other metabolic stressors and precipitate, for example, pulmonary hypertension [171], sleep-disordered breathing [172], hypertension [173] or foetal growth restriction [170], which are associated with either ascent to altitude [2,30] and/or metabolic syndrome-related disorders [172,174,175]. This evidence concerns the gene PRKAA1 and hypertensive disorder.