In acute monocytic leukemia cells THP-1, NOD2 (Nucleotide-binding and oligomerization domain-2, an immune receptor to intracellular bacterial lipopolysaccharides) was found to interact with OAS2 enhancing RNase-L function, indicating a connection between OAS2 and other innate immune signaling pathways11. Here, NOD2 is linked to acute monocytic leukemia.