Elevated phosphorylation can lead to increased Po of LTCCs.25 Also, CaMKII activity is elevated in HF,26 and CaMKII can phosphorylate LTCCs at specific sites.27 Therefore, we tested the hypothesis that the elevated activity of CaMKII in failing cardiac myocytes is responsible for phosphorylation and, thus, for the high Po of LTCCs in crest. This evidence concerns the gene CAMK2G and hydrops fetalis.