CDKN2A and neoplasm: Although, we have not observed significant changes in VEGF levels when gene expression was analyzed in whole tumor, probably due to the existence of a mixed of tumor and stromal cells; analysis of TAMs isolated from the tumors of ARF−/− mice revealed an important increment in VEGF expression, similarly as was observed when ARF−/− macrophages were exposed to the CM from B16F10 tumor cells.