To investigate the underlying mechanisms by which SHCBP1 promotes proliferation of SS cells, we explored the effects of SHCBP1 silencing on the activity of MAPK/ERK and PI3K/AKT/mTOR signaling pathways which are important in the pathogenesis of various tumors [35–37] including SS [38, 39]. The gene discussed is AKT1; the disease is synovial sarcoma.