On the contrast, the AN3CA xenografts with PTEN knock-in became much more sensitive to JQ1 than their parental ones after 4 weeks of treatment, accompanied by a decrease in tumor weights (Figure 5E and 5F), while IHC results showed that expression levels of Ki-67 and phosphorylated-AKT were decreased in the tumor tissues in AN3CA xenografts with PTEN knock-in treated with JQ1 (p = 0.041 and 0.018, respectively, Figure 5G and 5H). This evidence concerns the gene AKT1 and neoplasm.