Because SETDB2 knockdown led to significant inhibition of cell growth, migration and invasion, we further selected six tumor- or differentiation-related genes (WWOX, CADM1/TSLC1, CCDC80, NDRG1, CA9 and FZD9) that have been reported to show altered expression in several cancers including GCs [13–18]. Here, WWOX is linked to neoplasm.