Since WWOX is known to play a role as a TSG in various cancers [19, 20], we studied the relationship between SETDB2 and WWOX. SETDB2 knockdown up-regulated WWOX protein expression in MKN74 and MKN45 cells, and, conversely, SETDB2 overexpression in AGS and NUGC3 cells repressed the protein expression of WWOX (Figure 5B). The gene discussed is SETDB2; the disease is cancer.