In future studies, it will be interesting to test the effect of apoA1 or CyD infusion in pre-clinical models of ischemia reperfusion injury (mimicking a myocardial infarction), septic shock or ischemic stroke, all of which are situations where limiting the initial rush of inflammatory leukocytes into sites of injury could have a significant effect on subsequent tissue injury and repair processes. The gene discussed is APOA1; the disease is ischemic stroke.