None of the family members carried the rare AMD risk alleles at CFH R53C, CFH D90G, CFH P503A, or CFH R1210C14, 15, 16, 18 nor did they carry risk alleles for macular diseases in the BEST1, ABCA4, or other retinal degeneration-associated genes25. Here, CFH is linked to age-related macular degeneration.