CD4 and tuberculosis: We are currently conducting a randomized controlled trial (the PredART trial) in Khayelitsha, South Africa, with the primary objective to determine whether a 4-week course of prednisone in patients at high risk for TB-IRIS (starting ART within 30 days of starting treatment for TB and a CD4 count of ≤100/μL) reduces the incidence of TB-IRIS.