The western blot results revealed that EF24 decreased the expression of XIAP and increased the expression of cleaved caspase-9 and caspase-3 (Fig. 5C).The positive tumor cells for Ki-67, a cell proliferation marker, were substantially less in tumors treated with EF24, compared with control tumors (Fig. 5D). This evidence concerns the gene CASP3 and neoplasm.