Prakobwong and colleagues reported that curcumin stimulated antiproliferative and apoptotic effects in CCA through multiple cell signaling pathways, including the inhibition of cell survival protein expression such as Bcl-2, Bcl-xL, X-linked inhibitor of apoptosis protein, c-FLIP, cellular inhibitor of apoptosis protein (cIAP)-1, cIAP-2 and surviving15. The gene discussed is XIAP; the disease is cholangiocarcinoma.