In summary, we revealed that two common dysfunctional variants (Q126X and Q141K) of ABCG2 have a significant negative effect on both intestinal and renal urate excretion in humans, and that intestinal and renal ABCG2 dysfunction markedly increases SUA in end-stage renal disease and acute gastroenteritis. The gene discussed is ABCG2; the disease is stage 5 chronic kidney disease.