ACE2 and abdominal aortic aneurysm: In hypercholesterolemic mice on a wild-type or ACE2 deficient background with Ang II induced abdominal aortic aneurysms [34], 4-weeks of intramuscular DIZE (30mg/kg) increased kidney ACE2 mRNA and activity in wild-type mice, and reduced the incidence and severity of Ang II-induced abdominal aortic aneurysms.