WNT5A and ovarian carcinoma: In this study, Wnt5a reconstitution in primary human ovarian surface epithelial cells, the epithelial ovarian cancer cell line OVCAR5 and an in vivo model induced cellular senescence through increasing recruitment of histone repressor A (HIRA) into PML bodies, a main mechanism in senescence, and this process was independent of p53 and p16INK4a [34].