WNT5A and gastric cancer: In gastric cancer, Wnt5a induced the expression of the extracellular matrix protein lamininγ2, a subunit of the extracellular matrix laminin 5 protein that constitutes the epithelial basement membrane, through activating Dvl-associating protein with a high frequency of leucine residues (Daple), which in turn activates Rac and JNK to promote invasion and metastasis [98].