WNT5A and melanoma: Furthermore, Wnt5a also disrupts the N-cadherin and β-catenin complexes by binding to Fzd4/LRP6 receptor complex and activating ARF6, thereby increasing the pool of free β-catenin in the cytoplasm, which translocates to the nucleus, enhances β-catenin-mediated transcription, and stimulates melanoma cells invasion [91].