Another study on prostate cancer showed that Wnt5a bound to Fzd2 and Ror2 and activated JNK signaling, leading to expression of matrix metalloproteinase 1 (MMP1) through enhancing the recruitment of JunD to the AP-1 site of MMP1 promoter region, thereby inducing cell migration and invasion [94]. This evidence concerns the gene MMP1 and Familial prostate cancer.