In their quest to elucidate CML resistance towards tyrosine kinase inhibitors (TKI), they show the importance of the Wnt/Ca2+/NFAT pathway (a non-canonical Wnt pathway) in resistant CML cells and in particular the role of Fzd8. The gene discussed is FZD8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.