ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Normally, BCR-ABL-transduced cells cause a ratio of CML/ALL of 4:1 in the transplanted mice, however, when using Bcr-Abl-transduced cells lacking β-catenin (β-catenin −/−) this ratio was reversed (only 20% of the mice develop CML versus 80% of the mice that develop ALL) [52].