BTK and acute lymphoblastic leukemia: In addition, when combined with treatments for classical abnormalities (targeted by tyrosine kinase inhibitors in CML (imatinib, dasatinib) [47,88], Notch inhibitors in T-ALL [89], and BTK inhibitors in precursor B-ALL (ibrutinib) [90]), the necessary dosage of Wnt inhibitors is expected to be lower as one can envision combination therapies targeting Wnt signaling together with the other genetic alterations to work synergistically.