PLA2G2A and Sepsis: While these 1H-indole-3-glyoxylamides and related PLA2 inhibitors have failed as treatments for several chronic and acute conditions (e.g., rheumatoid arthritis, sepsis and acute coronary syndromes) in late-phase clinical trials [45,46,47,48,49] they have a good short-term safety profile [32,45,46,47] and to our knowledge have never previously been considered for treatment of snakebite [2].