ICAM1 and cancer: However, in a recent study Effenberger et al. [62] investigated how transmembrane proteins are secreted from senescent cancer cells, showing that the release from cell surface of the epidermal growth factor receptor (EGFR) ligand amphiregulin and the tumor necrosis factor (TNF) receptor I is mediated by ADAM metallopeptidase domain 17 (ADAM 17) protease via ectodomain shedding, whereas the release of intercellular adhesion molecule 1 (ICAM1), which is a ligand for lymphocyte function-associated antigen-1 (LFA-1) receptor on leukocytes, is due to microvesicles shedding.