However, ADAM9, through other mechanisms, has been linked with the regulation of the tumor growth of various other human cancers; for example, the silencing of ADAM9 has been shown to reduce tumor cell proliferation and the migration of esophageal squamous cell carcinoma cells by inhibiting epidermal growth factor receptor (EGFR)/protein kinase B (AKT) signaling [42]. The gene discussed is EGFR; the disease is esophageal squamous cell carcinoma.